abstract：BACKGROUND:Many patients with asthma require an inhaled long-acting beta(2)-agonist (LABA) in addition to an inhaled corticosteroid to adequately control their disease. OBJECTIVE:The purpose of this study was to assess the long-term tolerability of a salmeterol xinafoate/ fluticasone propionate (SFC) hydrofluoroalkane...

journal_title：Clinical therapeutics

authors： Cowie RL,Boulet LP,Keith PK,Scott-Wilson CA,House KW,Dorinsky PM

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:Varenicline, a selective alpha4beta2 nicotinic acetylcholine receptor partial agonist, has been developed specifically for smoking cessation. In Japan, 39.3% of men smoke and this is a major public health concern. OBJECTIVE:The primary objective of this study was to evaluate the efficacy and dose-response r...

journal_title：Clinical therapeutics

authors： Nakamura M,Oshima A,Fujimoto Y,Maruyama N,Ishibashi T,Reeves KR

更新日期：2007-06-01 00:00:00

abstract：INTRODUCTION:Hemorrhagic cystitis is a potentially life-threatening complication in patients receiving cancer therapy. This urologic emergency is commonly associated with the chemotherapeutic use of oxazaphosphorine alkylating agents. This report describes a case of hemorrhagic cystitis associated with dacarbazine trea...

journal_title：Clinical therapeutics

authors： Mohammadianpanah M,Shirazi M,Mosalaei A,Omidvari S,Ahmadloo N

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:In this era of evidence-based medicine, clinicians require a comprehensive range of well-designed studies to support prescribing decisions and patient management. In recent years, data from observational studies have become an increasingly important source of evidence because of improvements in observational...

journal_title：Clinical therapeutics

authors： Ligthelm RJ,Borzì V,Gumprecht J,Kawamori R,Wenying Y,Valensi P

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:Inhaled dry powder insulin (IDPI) is the first inhaled insulin approved for the treatment of type 1 and type 2 diabetes mellitus (DM). OBJECTIVE:This article reviews available information on IDPI, focusing on its clinical pharmacokinetics, comparative efficacy, tolerability, adverse events, dosage and admin...

journal_title：Clinical therapeutics

authors： Setter SM,Levien TL,Iltz JL,Odegard PS,Neumiller JJ,Baker DE,Campbell RK

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Antidepressants have been commonly used by women of childbearing age. Recent studies suggest that paroxetine, a selective serotonin reuptake inhibitor (SSRI), might specifically increase teratogenic risk. OBJECTIVES:The purpose of this study was to quantify first-trimester exposure to paroxetine and birth d...

journal_title：Clinical therapeutics

authors： Bar-Oz B,Einarson T,Einarson A,Boskovic R,O'Brien L,Malm H,Bérard A,Koren G

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Patients with hypertension may require combination therapy to attain the blood pressure targets recommended by US and European treatment guidelines. Combination therapy with a calcium channel blocker and an angiotensin II-receptor blocker would be expected to provide enhanced efficacy. OBJECTIVES:Two studie...

journal_title：Clinical therapeutics

authors： Philipp T,Smith TR,Glazer R,Wernsing M,Yen J,Jin J,Schneider H,Pospiech R

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:Terazosin is an alpha1-selective adrenoceptor blocking agent that has been reported in many clinical trials to be an effective choice for the treatment of benign prostatic hyperplasia (BPH). To improve cost-effectiveness, the development of an effective and well-tolerated generic formulation is needed. OBJE...

journal_title：Clinical therapeutics

authors： Tsai YS,Lan SK,Ou JH,Tzai TS

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:Trials of monotherapy with alpha(1)-adrenergic-receptor antagonists (alpha(1)ARAs) and 5 alpha-reductase inhibitors (5ARIs) have found that the former drug class is effective in managing benign prostatic hyperplasia (BPH)-related lower urinary tract symptoms (LUTS) and improving the maximal urinary flow rate...

journal_title：Clinical therapeutics

authors： McVary KT

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Patients' preferences for medications may be important in determining their compliance with therapy, particularly in the case of an asymptomatic chronic disease such as osteoporosis. Although preferences for certain attributes of osteoporosis medications, including dosing frequency and tolerability, can be e...

journal_title：Clinical therapeutics

authors： Duarte JW,Bolge SC,Sen SS

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Most patients with hypertension in the United States and Europe fail to achieve the recommended target blood pressure (BP) of <140/90 mm Hg. Combination therapy is required in approximately two thirds of all patients whose BP is >20/10 mm Hg above the goal. Combination therapy with agents having complementar...

journal_title：Clinical therapeutics

authors： Poldermans D,Glazes R,Kargiannis S,Wernsing M,Kaczor J,Chiang YT,Yen J,Gamboa R,Fomina I

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:In the past decade, health insurers have increased their reliance on cost control policies such as prior authorization and 3-tier formularies. Little is known about how these policies are being applied to psychotropic medications, many of which have low rates of patient adherence. OBJECTIVE:This study repor...

journal_title：Clinical therapeutics

authors： Hodgkin D,Horgan CM,Garnick DW,Len Merrick E,Volpe-Vartanian J

更新日期：2007-02-01 00:00:00

abstract：OBJECTIVE:This post hoc analysis was aimed to summarize the efficacy and tolerability of duloxetine as represented by number needed to treat (NNT) and number needed to harm (NNH) to provide a clinically useful assessment of the position of duloxetine among current agents used to treat diabetic peripheral neuropathic pa...

journal_title：Clinical therapeutics

authors： Kajdasz DK,Iyengar S,Desaiah D,Backonja MM,Farrar JT,Fishbain DA,Jensen TS,Rowbotham MC,Sang CN,Ziegler D,McQuay HJ

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Outcomes in patients with type 2 diabetes mellitus (DM) can differ based on the antidiabetic medication that is used. Thiazolidinediones (TZDs) are a newer class of agents used for the treatment of type 2 DM. No previous study has compared health care utilization associated with the 2 TZDs on the market. OB...

journal_title：Clinical therapeutics

authors： Balkrishnan R,Arondekar BV,Camacho FT,Shenolikar RA,Horblyuk R,Anderson RT

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Many patients and physicians interpret episodic headache in the presence or absence of nasal symptoms as "sinus' headache, while ignoring the possible diagnosis of migraine. OBJECTIVE:The purpose of this study was to assess the efficacy and tolerability of sumatriptan succinate 50-mg tablets in patients wit...

journal_title：Clinical therapeutics

authors： Ishkanian G,Blumenthal H,Webster CJ,Richardson MS,Ames M

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVES:This study was conducted to estimate the prevalence of antipsychotic polypharmacy among fee-for service state Medicaid beneficiaries initiating antipsychotic drug therapy and to investigate psychiatric and demographic predictors of such polypharmacy. METHODS:This was a retrospective cohort study employing M...

journal_title：Clinical therapeutics

authors： Morrato EH,Dodd S,Oderda G,Haxby DG,Allen R,Valuck RJ

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to evaluate the annhypertensive efficacy and tolerability of the angiotensin-converting enzyme inhibitor imidapril and the angiotensin II type 1 receptor antagonist candesartan in mild to moderate essential hypertension. METHODS:The trial was conducted at 8 centers across Portugal a...

journal_title：Clinical therapeutics

authors： Palma Gámiz JL,Pêgo M,Contreras EM,Anglada MP,Martínez JO,Esquerra EA,Sagastagoitia Gorostiza JD,Iberian Multicenter Imidapril Study on Hypertension.

更新日期：2006-12-01 00:00:00

abstract：OBJECTIVE:This study describes patients' and physicians' perceptions of issues related to dosing adherence with topical therapies for lowering intraocular pressure before and after use of the travoprost dosing aid (Travatan Dosing Aid, Alcon Research Ltd., Fort Worth, Texas). METHODS:The study had an open-label, multi...

journal_title：Clinical therapeutics

authors： Flowers B,Wand M,Piltz-Seymour J,Berke SJ,Day D,Teague J,Smoot TM,Landry TA,Bergamini MV,Mallick S,Travatan Dosing Aid Study Group.

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Attention-deficit/hyperactivity disorder (ADHD) has a substantial negative impact; however, within long-term follow-up studies, a proportion of patients do very well, both symptomatically and functionally, suggesting that the lower the symptom burden, the greater the functional improvements. Studies in major...

journal_title：Clinical therapeutics

authors： Steele M,Jensen PS,Quinn DM

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Recent developments in pharmacologic and device therapy, as well as initiatives to increase the use of standard orders and promote in-hospital communication, have improved the care of patients with myocardial infarction (MI). The increased presence of hospitalists, physicians who provide in-hospital care as ...

journal_title：Clinical therapeutics

authors： Amin A

更新日期：2006-10-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to test the ability of human insulin 70/30, insulin lispro mixture 75/25 (75% neutral protamine lispro [NPL], 25% insulin lispro), and insulin lispro mixture 50/50 (50% NPL, 50% insulin lispro) to control postprandial glucose (PPG) concentrations in patients with type 2 diabetes mell...

journal_title：Clinical therapeutics

authors： Schwartz S,Zagar AJ,Althouse SK,Pinaire JA,Holcombe JH

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND:The off-label use of beta-blockers might be prevalent, but no studies have provided empiric data on the off-label use based on utilization data. OBJECTIVE:This secondary data analysis was conducted to describe the trends of off-label use of beta-blockers among ambulatory visits made to office-based physicia...

journal_title：Clinical therapeutics

authors： Lin HW,Phan K,Lin SJ

更新日期：2006-10-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to determine the time to onset of pain relief from a single dose of a tablet formulation of paracetamol (acetaminophen) containing sodium bicarbonate (PSC). METHODS:A single oral dose of PSC or placebo was randomly administered to patients with acute sore throat under double-blind c...

journal_title：Clinical therapeutics

authors： Burnett I,Schachtel B,Sanner K,Bey M,Grattan T,Littlejohn S

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:Despite increasing investigation in the area of cardiovascular instability in preterm infants, huge gaps in knowledge remain. None of the current treatments for hypotension, including the use of inotropic agents, have been well studied in the preterm population, and data regarding safety and efficacy are lac...

journal_title：Clinical therapeutics

authors： Evans JR,Lou Short B,Van Meurs K,Cheryl Sachs H

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:Older adults may have decreased homeostatic reserve, have multiple chronic diseases, and take multiple medications. Therefore, they are at risk for adverse outcomes after receiving a drug that exacerbates a chronic disease. OBJECTIVES:The aims of this study were to compile a list of clinically important dru...

journal_title：Clinical therapeutics

authors： Lindblad CI,Hanlon JT,Gross CR,Sloane RJ,Pieper CF,Hajjar ER,Ruby CM,Schmader KE,Multidisciplinary Consensus Panel

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:In Taiwan, a policy of separation of prescribing and dispensing practices of practitioners at Western medical and dental clinics was implemented on an incremental basis in 1997. The purpose of this policy was to promote pharmacists' autonomy and increase the transparency and safety of prescribing medications...

journal_title：Clinical therapeutics

authors： Ji Chen T,Chou LF,Hwang SJ

更新日期：2006-08-01 00:00:00

abstract：OBJECTIVE:These studies assessed the comparative efficacy of rofecoxib and valdecoxib in the treatment of acute postoperative dental pain. METHODS:Two randomized, double-blind, placebo-controlled, single-dose studies were conducted in patients undergoing extraction of > or =2 third molars, with > or =1 mandibular impa...

journal_title：Clinical therapeutics

authors： Daniels SE,Desjardins PJ,Bird SR,Smugar SS,Tershakovec AM

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:Patients and physicians consider rapid onset of pain relief and pain freedom among the most important attributes of migraine therapy. OBJECTIVE:This study compared the effectiveness of rizatriptan 10 mg and usual-care oral migraine medications in everyday clinical practice settings. METHODS:This was a mult...

journal_title：Clinical therapeutics

authors： Bell CF,Foley KA,Barlas S,Solomon G,Hu XH

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:To date, few postmarketing studies have addressed whether long-term prophylactic treatment with second-generation antidepressants (ADs) delays depressive episodes in patients with bipolar disorder. OBJECTIVE:The aim of this study was to compare the risk of depressive relapse between patients with bipolar di...

journal_title：Clinical therapeutics

authors： Fu AZ,Christensen DB,Hansen RA,Liu GG

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:Although the metabolic effects of the thiazolidinediones have been well studied, there is a lack of comparative data on their effects on certain cardiovascular risk factors, such as elevated plasma levels of lipoprotein (a) (Lp[a]) and homocysteine (Hcy). OBJECTIVE:This study compared the effects of pioglit...

journal_title：Clinical therapeutics

authors： Derosa G,Cicero AF,D'Angelo A,Gaddi A,Ciccarelli L,Piccinni MN,Salvadeo SA,Pricolo F,Ferrari I,Gravina A,Ragonesi PD

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:Fever in children is a common and usually benign symptom. It is known that antipyretic treatment is ineffective in the prevention of simple febrile seizures. Caregivers' administration of antipyretic medications to children has been reported, but data concerning the formulations used, actual doses administer...

journal_title：Clinical therapeutics

authors： Bilenko N,Tessler H,Okbe R,Press J,Gorodischer R

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:Mitoxantrone, an intravenously administered immunosuppressant that inhibits T-cell, B-cell, and macrophage proliferation, is indicated for reducing neurologic disability and relapse frequency in patients with secondary progressive multiple sclerosis (SPMS), progressive relapsing MS, or worsening relapsing-re...

journal_title：Clinical therapeutics

authors： Fox EJ

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:Coronary heart disease (CHD) is the leading cause of death in men and women in the United States, with a higher mortality in women, despite a lower prevalence. Statins effectively treat dyslipidemia and reduce the risk of CHD mortality. OBJECTIVE:The objective of this study was to evaluate the treatment of ...

journal_title：Clinical therapeutics

authors： Cooke CE,Hammerash WJ Jr

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND:Oxymorphone extended release (ER) is a tablet formulation of the mu-opioid agonist oxymorphone designed to achieve a low peak-to-trough fluctuation in plasma concentrations over a 12-hour dosing period. OBJECTIVE:This study compared the analgesic efficacy, dose response, and tolerability of 3 doses of oxymo...

journal_title：Clinical therapeutics

authors： Kivitz A,Ma C,Ahdieh H,Galer BS

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:The therapeutic effectiveness of Echinacea in the treatment and the prevention of colds has been debated. Studies of naturally occurring colds are hampered by variability in time from onset of symptoms to treatment and by heterogeneity in trial design. Experimental infection studies allow for the standardiza...

journal_title：Clinical therapeutics

authors： Schoop R,Klein P,Suter A,Johnston SL

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:Dipeptidyl peptidase-IV (DPP-IV) inhibitors represent a new class of oral antihyperglycemic agents. Sitagliptin is an orally active and selective DPP-IV inhibitor currently in Phase III development for the treatment of type 2 diabetes mellitus. OBJECTIVE:The aim of this study was to assess the pharmacokinet...

journal_title：Clinical therapeutics

authors： Bergman AJ,Stevens C,Zhou Y,Yi B,Laethem M,De Smet M,Snyder K,Hilliard D,Tanaka W,Zeng W,Tanen M,Wang AQ,Chen L,Winchell G,Davies MJ,Ramael S,Wagner JA,Herman GA

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:In the United States, patients with high-risk stage II or III melanoma are often treated with adjuvant interferon (IFN) therapy for 1 year after surgery. Adverse events associated with IFN alfa-2b use are primarily constitutional symptoms. However, hypertriglyceridemia requiring treatment has been reported. ...

journal_title：Clinical therapeutics

authors： Wong SF,Jakowatz JG,Taheri R

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:High incidences of cardiovascular events coincide with a surge in blood pressure (BP) that occurs in the early morning hours at the time of arousal. Thus, control of BP at this time of day, using oral fixed-dose combinations (FDCs) as required, is important in reducing cardiovascular risk in hypertensive pat...

journal_title：Clinical therapeutics

authors： Lacourcière Y,Neutel JM,Schumacher H

更新日期：2005-11-01 00:00:00

abstract：OBJECTIVE:This study evaluated the efficacy and tolerability of glimepiride in patients with type 2 diabetes mellitus that was inadequately controlled with a combination of immediate- or extended-release metformin and a thiazolidinedione. METHODS:This was a multicenter, randomized, double-blind, placebo-controlled, pa...

journal_title：Clinical therapeutics

authors： Roberts VL,Stewart J,Issa M,Lake B,Melis R

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND:Partial seizure disorder is typically treated by monotherapy with antiepileptic drugs (AEDs). However, when the condition is refractory to the initial treatment regimen, patients may be switched to monotherapy with another AED or to combination therapy with the initial AED plus a second AED. OBJECTIVES:The ...

journal_title：Clinical therapeutics

authors： Lee WC,Hoffmann MS,Arcona S,D'Souza J,Wang Q,Pashos CL

更新日期：2005-10-01 00:00:00